For quake, the best options are:
http://www.binaryriot.org/kiero/GLQuake.lha
http://bigfoot.morphos-team.net/files/f ... 31-675.lha
(I doubt on the Efika you can use higher res textures with fuhquake, but if it works it is indeed a very nice quakeworld client)

For IRC:
http://www.biclodon.com/software/amirc/
It's shareware, but I doubt you can get a key nowadays...
This one is donationware but without restrictions:
http://wookiechat.amigarevolution.com/wookiechat/

A good list of native software was here (sadly it's not updated anymore since many months, but it is a good starting point anyway):
http://www.morphos-news.de/software.php?lg=en

Kind regards,
Andrea

Lukas Stehlik has the best software list that I know of. It's easy to find it updated every day!

http://pegasos.kvalitne.cz/software/en